YÜKSEK LİSANS DERS İÇERİKLERİ

Kodu

Ders Adı

İÇERİK
TR

İÇERİK ENG

BENG500

Seminar-Seminer

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BENG501

Molecular Biology for Engineers-Mühendisler için Moleküler Biyoloji

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BENG502

Emerging Topics in Biotechnology-Biyoteknolojide Güncel Konular

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BENG504

Advanced Molecular Biology-İleri Moleküler Biyoloji

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BENG505

Current Topics In Molecular Biology-Moleküler Biyolojide Güncel Konular

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BENG506

Bioinformatics-Biyoinformatik

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BENG507

Human Molecular Genetics-İnsan Moleküler Genetiği

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BENG508

Advanced Cell Biology-İleri Hücre Biyolojisi

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BENG509

Introduction to Nanobiotechnology-Nanoteknolojiye Giriş

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BENG510

Applied Biochemistry-Uygulamalı Biyokimya

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BENG511

Moleculer Biology Laboratory for Engineers-Mühendisler İçin Moleküler Biyoloji Labaratuvarı

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BENG512

Biotechnology and Biosafety-Biyoteknoloji ve Biyogüvenlik

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BENG513

Ethics in Biotechnology-Biyoteknolojide Etik

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BENG514

Cancer Biology and Treatment-Kanser Biyolojisi ve Tedavi

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BENG515

Introduction to Tissue Engineering-Doku Mühendisliğine Giriş

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BENG516

Tissue Engineering and Regenerative Medicine-Doku Mühendisliği ve Yenileyici Tıp

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BENG517

Polymeric Biomaterials- Polimerik Biyomalzemeler

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BENG518

Biomaterials-Biyomalzemeler

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BENG519

Physiology-Fizyoloji

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BENG520

Artificial Organs-Yapay Organlar

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BENG521

Biomedical Electronics-Biyomedikal Elektronik

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BENG522

Biomechanics-Biyomekanik

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BENG523

Multifunctionel Polymeric Nanocarriers-Çok İşlevli Polimerik Nanotaşıyıcılar

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BENG524

Materials Design and Fabrication for Tissue Engineering-Doku Mühendisliği için Malzeme Tasarımı ve Fabrikasyonu

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BENG525

Instrumental Analysis-Enstrümental Analiz

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BENG526

Basic Patent Principles in Science and Engineering-Patent Uygulamalarının Temel İlkeleri

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BENG527

Biosensors-Biyosensörler

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BENG528

Polymer Science-Polimer Bilimi

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BENG529

Nanofabrication for Biological Applications-Nanofabrikasyonun Biyolojik Uygulamaları

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BENG530

Basic Engineering for Bioengineers-Biyomühendisler İçin Temel Mühendislik

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BENG531

Biosignal and Image Analysis-Biyosinyal ve Görüntü Analizi

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BENG532

Medical Imaging-Medikal Görüntüleme

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BENG533

Biophysics-Biyofizik

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BENG534

Research Techniques in Bioengineering-Biyomühendislikte Araştırma Teknikleri

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BENG535

Molecular & Statistical Mechanics-Moleküler&İstatistiksel Mekanik

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BENG536

Linux For Scientific Research-Bilimsel Araştırma İçin Linux

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BENG537

Stem Cells-Kök Hücreler

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BENG538

Biological Sciences for Bioengineers-Biyomühendisler için Biyolojik Bilimler

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BENG539

Nanocarriers and Drug Delivery-Nanotaşıyıcılar ve İlaç Salımı

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BENG540

Neuron Dynamics-Nöron Dinamiği

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BENG541

Molecular Cell Biology for Engineers-Mühendisler için Moleküler Hücre Biyolojisi

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BENG542

Hastalıkların Moleküler Temeli

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BENG545

Protein Ekspresyonu ve Saflaştırılması Pdf Pdf
BENG546

Veri Madenciliği

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BENG597

MS Special Topics- Yüksek Lisans Uzmanlık Alan Dersi

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BENG599

MS Thesis-Yüksek Lisans Tez Çalışması

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DOKTORA DERS İÇERİKLERİ

BENG601 Emerging Topics in Biotechnology

This seminar-style, capstone course is an in-depth exploration of emerging technologies, innovations, and new products that are noteworthy to the biotechnology industry. The first half of the course focuses on examining and critiquing what new scientific discoveries will likely impact the industry and in what ways. In the second half of the course, students, working in teams, will give written and oral presentations on case studies that attempt to predict products derived from the new innovations and discoveries. The objective of the course is to give the student insight into the process of translating scientific discovery into innovative products.

BENG602 Introduction to Nanobiotechnology: Concepts and Applications

This course provides perspective for students and researchers who are interested in nanoscale physical and biological systems and their applications in medicine. It introduces concepts in nanomaterials and their use with biocomponents to synthesize and address larger systems. Applications include systems for visualization, labeling, drug delivery, and cancer research. Technological impact of nanoscale systems, synthesis, and characterizations of nanoscale materials are discussed.

BENG603 Ethics in Biotechnology

History of bioengineering, definition of bioengineering, research, publishing principles and human and animal rights in terms of technology, place of environmental consciousness on the application of bioengineering subjects and important ethical terms, legal and social laws.

BENG604 Tissue Engineering and Regenerative Medicine

Basics concepts of tissue engineering andregenerative medicine field will be covered in the first part of the course. The repair and regeneration of varying tissues for therapeutic purposes will be discussed.  Mechanism of cell differentiation into specific tissues in response to biological signal molecules will be explored. Cellular mechanism involved in animal clonning. Molecular basis of cellular tissue remodelling and regeneration fort he discovery of new drugs.

BENG605 Artificial Organs

Introduction to artificial organs. Mass transfer and basic principles of fluid mechanics.  Chemical reactions in biological systems. Information on biomaterials. Basic principles of artificial organ design (biomimetics). Effects of artificial organs on the development of society health. Mass transfer. Basic principles of fluid mechanics. Chemical reactions in biological systems. Chemical reactions in biological systems. Basic components of biological systems. Working principles of biological systems. Production of biomaterials used in artificial organs. Basic principles of artificial organ design (biomimetics). Artificial organ (heart, lung, kidney, etc) design Effects of artificial organs on the development of society health.

BENG606 Biomechanics

Introduction to biomechanics and muscle-skeletal system. Introduction to Biomechanics in biological systems and transport process. Dynamics of mechanical systems. Dynamics of muscle and arthrosis. Response of living tissues under the strain. Application methods of mechanical engineering on human muscle- skeletal system. Mechanical properties of tissues. Investigation of orthopedic materials and mechanical properties. Tension and deformations on materials. Analysis of fracture-crack, fracture-crack fictions, frictional, polish and overwear, process of implants. Headlines on heart dynamics and heart beating, blood circulation, microcirculation and muscle mechanics. Modern developments on biomechanics at advanced mathematical level. Main research areas and problems related with biomechanics.

BENG607 Multifunctional Polymeric Nanocarriers

Multifunctional nanocarriers and main characteristics. A typical nanocarrier. Pathways and problems in drug delivery. Types of nanocarriers: liposomes, inorganics, polymeric nanoparticles, micelles, etc. Polymeric nanoparticle preparation methods (emulsion, phase separation, coaservation). Micelle formation; controlled polymerization for uniform polymer chains (RAFT, ATRP). Cross-linked micelles. Stimuli-responsive systems. Drug-conjugated systems. Surface modification, PEGylation. Targeting ligands and targeting approaches.

BENG608 Biosensors

Underlying engineering principles used to detect small molecules, DNA, proteins, and cells in the context of applications in diagnostic testing, pharmaceutical research, and environmental monitoring. Biosensor approaches including electrochemistry, fluorescence, acoustics, and optics; aspects of selective surface chemistry including methods for biomolecule attachment to transducer surfaces; characterization of biosensor performance; blood glucose detection; fluorescent DNA microarrays; label-free biochips; bead-based assay methods. Case studies and analysis of commercial biosensors.

BENG609Advanced Polymer Science

Polymer terminology, nomenclature. Stereochemistry in polymers, conformation, configuration, isomerization, optical activity. Morphology of polymers, crystaline, amorphous and semi-crystalline polymers, glass-transition temperature, melting temperature. Methods for the molecular weight determination of polymers, colligative properties and molecular weight, size-exclusion chromatography, light-scattering, etc. Mechanical properties and other properties of polymers. Polymerization reactions, radical polymerization, addition polymerization, condensation polymerization, etc. Polymerization processes, bulk, solution, suspension, emulsion polymerizations. Processing of polymers.

BENG610 Nanofabrication for Biological Applications

Importance of surface characteristics for biological applications (i.e., biomaterials, biosensors). Lithography, optical and e-beam lithography; X-ray lithography, focused-ion lithography, soft lithography, imprinting lithography, Thin film deposition, physical vapor deposition, chemical vapor deposition; Etching: wet and dry; Self-assembling; Microelectromechanical systems.

BENG611 Medical Imaging

General characteristics of imaging systems; X-ray and CT: general principles, interaction of X-rays with tissues, contrast agents, imaging techniques, image reconstruction, radiation dose; Nuclear Medicine: general principles, radionuclide, radioactive decay, gamma camera, imaging techniques, SPECT, PET; Ultrasound imaging: general principles, interaction of acoustic waves with tissue, acoustic impedance, instrumentation, scanning modes, artifacts, blood velocity measurements, contrast agents; MR imaging: general principles, nuclear magnetism, magnetic resonance, instrumentation, imaging sequences, contrast agents, imaging techniques, functional MRI.

BENG612 Cell Death

Throughout this course students will learn how cells decide their mode of death based on stress and pathological conditions. In addition to that, we will identify the different classification of cell death processes and mechanisms. The different cell death processes that will be covered in the course are apoptosis, extrinsic apoptosis, mitochondrial permeability transition (MPT)-driven necrosis, necroptosis, ferroptosis, pyroptosis, parthanatos, entotic cell death, NETotic cell death, lysosome-dependent cell death, autophagy-dependent cell death, immunogenic cell death, cellular senescence, and mitotic catastrophe.

BENG613 Implant-Cell Interactions

Cell response on implant strongly governs the success of the treatment. This course aims to shed light on to the molecular and cellular interactions with the implant surfaces. The changes in cell structure will be analyzed both in normal and cancer cells. Based on topics covered student will be able to design implants which would enhance the cell response and minimize the post-surgical complications.

BENG614 Mechanical Properties of Biomaterials

This course aims to bring an understanding of the fundamental relationships between the mechanical properties of a range of biomaterials and the biomedical applications. Critical properties influencing the success of the application will be discussed by analyzing the current clinical applications. Students will learn how to characterize some of the main properties and implement this knowledge into the selection of an appropriate material specific to the application.

BENG615 Biomechanics of Human Lower Limb

Biomechanical analysis of human lower limb during activities of daily life, e.g. walking, sit to stand, stair climbing, running, etc… In this context, definitions, conventions and terms for human gait, temporal and stride measures, kinematics of activities, kinetics of activities will be examined and the reflections of these studies for prosthetic device design, rehabilitation device and therapy design or assistive device design will be conducted as well.

BENG616 Human-centered design and applications

In this course, students will apply their engineering knowledge to design devices that are focused on human needs. In this regard, prosthetics and exoskeleton designs are the field of interest. Students would have chances to apply their knowledge from previous their undergraduate courses. In a summary throughout the course students will be able to conduct: kinematics analysis of mechanisms, dynamics analysis of mechanisms, analysis of conceptual design and system modeling, analyses of multi-degree of freedom multi-body mechanisms for their design purposes. Students would eventually apply their knowledge into several mechanisms both in the simulation environment and with prototypes. For this purpose, students will also gain experience and knowledge on using machinery, building CAM models, assembly design and realization and also designing test environment and evaluating prototypes.

BENG617 Glyco-protein Engineering

Glyco-protein is a protein modified with a glycan via enzymatic reaction. Majority of the proteins in human body are glycosylated. This protein glycosylations have a profound structural and functional consequences.  Therefore, glycol-proteins need to be properly glycosylated. Especially, this is very important for therapeutic glyco-proteins which requires carefully control. In this course, the importance of protein glycosylation will be discussed in terms of the requirements for protein glycosylation, glycosylation machinery, techniques for characterization of glycoprotein, impact of glycosylation in human biology, and finally implication of these aspects of glycosylation in engineering of glyco-proteins for therapeutic applications.

BENG618 Recombinant DNA Technology

This course will introduce the theory and application of recombinant DNA technology. It will cover the steps involved in basic cloning strategy including different types of restriction enzymes, DNA ligase, types of vectors, and how they are used to create a recombinant DNA molecule. Making DNA and cDNA libraries to find a specific gene will be discussed. Specific techniques to analyze recombinant DNA molecules suchs as DNA sequencing will be covered. Finally, students will have a detailed knowledge about the applications of recombinant DNA technology in different fields .

BENG619 Proteomics and Metabolomics

Introduction to proteome and proteomics technology. General workflow for bottom-up and top-down proteomic approaches. Exploration of differential protein expression, post-translational modifications and protein-protein interactions (PPI).  Introduction to metabolome and metabolomics. Metabolite identification, pathway identification and pathway integration.

BENG620 Mass Spectrometry:

Basic concepts and principles of mass spectrometry. Ion sources and ionization (ESI, APCI, FAB, MALDI and others), analyzers (Magnetic-Sector, Quadrupole, Time-of-Flight, Ion-trap, FT-ICR), and detectors. Interpretation of mass spectral data. Examples of mass spectrometry methodologies in different biological applications.

BENG621 Cell Signaling

The course will provide a detailed knowledge of molecular mechanisms of cell signaling with emphasis on the significance of signal transduction in physiology (such as apoptosis, cell cycle regulation, gene transcription) and pathophysiology (such as cancer and cardiovascular disease). The main signalling pathways and their functional properties, including different types of receptors and their signalling pathways, G proteins, protein kinases will be discussed together with their model systems and regulation. Accordingly, therapeutic strategies designed to specifically target altered signaling pathways in diseases will be discussed.

BENG622 Machine Learning

This course covers the fundamental concepts of machine learning. We will also examine implementation of widely used machine learning methods such as SVM, Decision Tree, Random Forest, Naïve Bayes, k-means clustering and hierarchical clustering on various datasets (biological, medical etc.) by using data science platforms (e.g. KNIME, Weka).  

BENG623 Transgenic Mice

This course will focus on the theory behind generating transgenic mice. We will address DNA/RNA microinjection into zygotes, contrast techniques and embryonic stem cell transfer. We will also cover genetically engineered mice that are constructed to more precisely model human phenotypes and pathologies such as transgenic mice of oncology, cardiovascular disease, neurodegenerative and metabolic disorders, among others. Students will learn gene knock out technologies such as CRISPR/Cas, embryonic stem cells and homologous recombination, Cre/loxP system among others.

BENG624 Metastasis and Tumor Microenvironment

This course will introduce cancer, as a complex architecture comprised of different cell types and macromolecules that form intricate interactions for the good of the tumor “organ”. This course will discuss how tumor cells and other non-transformed specialized cells interact to constitute the “tumor microenvironment (TME)” and how this interaction facilitates the process of metastasis. In addition to that, the course will cover the multistages of metastasis that requires cancer cells to escape from the primary tumour, survive in the circulation, seed at distant sites and grow.